Cancer Genetic Testing
A family history of cancer can leave you with more questions than answers. Our Cancer Genetic Testing service analyses your DNA for inherited mutations linked to hereditary cancers, giving you clear, evidence-based insight to guide screening, prevention, and peace of mind.
Introduction
In the era of personalised medicine, genetic insights are transforming the way we approach oncology, turning the focus from reactive treatment to absolute prevention. Cancer Genetic Testing is becoming an increasingly vital tool in modern healthcare, allowing specialists to look directly into a person’s DNA to identify inherited mutations before an illness ever takes root. Rather than relying on a one-size-fits-all model, this advanced genomic approach empowers individuals to understand their biological blueprint, replacing clinical anxiety with definitive, actionable data.
This screening is particularly life-saving for identifying hereditary risks associated with a wide range of malignancies, including:
Breast and Ovarian Cancers: Primarily driven by inherited mutations in the well-known BRCA1 and BRCA2 genes.
Colorectal and Endometrial Cancers: Frequently linked to hereditary conditions like Lynch Syndrome, which affect the body’s natural DNA repair mechanisms.
Prostate and Pancreatic Cancers: Which often share overlapping genetic pathways with other hereditary cancer syndromes.
Uncovering these genetic markers allows families to take highly proactive steps, from enhanced diagnostic imaging to personalized, preventative care. At London Genetics, we combine cutting-edge science with expert clinical guidance, offering patients a trusted, compassionate pathway towards clarity, reassurance, and informed decision-making about their long-term health.
What is Cancer Genetic Testing?
Cancer Genetic Testing is a specialised medical procedure that examines a person’s DNA to identify inherited changes, or mutations, which may increase the likelihood of developing certain types of cancer. These genetic variations are passed down through families and can significantly influence an individual’s lifetime cancer risk.
Unlike diagnostic tests performed once a tumour has already been found, genetic testing focuses on what is present in every cell of the body from birth — the inherited code of life. By pinpointing these changes, doctors can determine whether a person has a higher-than-average risk of developing cancers such as breast, ovarian, colorectal, pancreatic, or prostate cancer.
Genetic testing for cancer risk is usually recommended when:
There is a strong family history of particular cancers.
An individual is diagnosed with cancer at a young age.
Multiple cancers have appeared within the same family line.
The test itself is relatively simple. A small sample of blood or saliva is collected and analysed in a laboratory. Advanced techniques, such as next-generation sequencing, are used to examine specific genes known to be linked with hereditary cancers — for example, BRCA1 and BRCA2, which are strongly associated with breast and ovarian cancer.
The results of Cancer Genetic Testing can offer powerful insights. A positive result may confirm the presence of a high-risk mutation, allowing patients and clinicians to put tailored screening or preventative measures in place. A negative result can provide reassurance, though it does not rule out all cancer risks entirely. In some cases, results may show a “variant of uncertain significance” (VUS), where the genetic change is identified but its impact on cancer risk is not yet fully understood.
In every scenario, genetic counselling plays a vital role. Trained professionals help patients interpret the findings, consider the implications for their health and their family members, and make informed choices about next steps.
By moving beyond a one-size-fits-all approach, Cancer Genetic Testing empowers people with knowledge that can guide early intervention, personalised care, and more effective prevention strategies.
Who Should Consider Cancer Genetic Testing?
Not everyone needs to undergo Cancer Genetic Testing, but for certain individuals it can provide vital information about their health risks. This type of testing is most often recommended when personal or family history suggests that cancer may be linked to inherited genetic changes.
If several close relatives on the same side of the family have been diagnosed with the same or related types of cancer, genetic testing may be advised.
Cancers such as breast, bowel, or ovarian cancer that develop well before the typical age range can indicate inherited genetic changes.
When a person has been diagnosed with more than one type of cancer during their lifetime, genetic testing can help uncover underlying causes.
Certain rare cancers, such as sarcomas, male breast cancer, or combinations of cancers linked to hereditary syndromes, may suggest inherited risks.
If your family carries a mutation in genes such as BRCA1, BRCA2, or those linked to Lynch syndrome, testing can clarify your personal risk.
Taking a proactive approach matters. Even if you don’t fall neatly into these categories, your GP or a genetic counsellor may still recommend testing. The goal is to identify higher-risk individuals and provide opportunities for early screening, lifestyle changes, or preventive care—helping you and your family make informed, confident decisions about your health.
The Process of Cancer Genetic Testing at London Genetics
At London Genetics, the process of Cancer Genetic Testing is designed to be thorough, supportive, and tailored to each individual’s circumstances. The aim is not only to analyse your DNA, but also to ensure that you fully understand what the test may reveal and how it could guide your healthcare choices.
1. Pre-test consultation and family history review
The journey begins with a detailed consultation. One of our specialists will take time to discuss your personal medical background and collect a comprehensive family history, focusing on any patterns of cancer across generations. This step helps us to assess whether genetic testing is appropriate, and if so, which specific tests are likely to provide the most meaningful information. Importantly, you will also be given the opportunity to ask questions and to consider the potential benefits and limitations before proceeding.
2. Sample collection
If testing is recommended and you decide to go ahead, the next step is straightforward. A small sample is taken — usually a simple blood draw or a saliva (spit) sample. Both methods are safe, quick, and minimally invasive.
3. Laboratory analysis
Your sample is then sent to a highly specialised genetics laboratory, where advanced techniques are used to examine your DNA for mutations linked to inherited cancer risk. Depending on your personal and family history, the test may focus on a single gene, such as BRCA1 or BRCA2, or involve a broader panel that screens multiple genes at once.
4. Results and follow-up
Once the analysis is complete, results are carefully reviewed by our clinical team. You will be invited to a follow-up consultation, where your specialist will explain the findings in clear, accessible language. Together, you can explore what the results mean for you, and where relevant, for your family members too.
This structured process ensures that patients at London Genetics receive not only cutting-edge scientific analysis, but also compassionate guidance throughout their journey — from the very first conversation to personalised recommendations after results are received.
Understanding the Results of Cancer Genetic Testing
The results of Cancer Genetic Testing can provide valuable insights, but they are not always straightforward. At London Genetics, our specialists guide you through the meaning of your results so that you can make well-informed decisions about your health and future care. Broadly, results fall into three main categories:
Positive Result
A positive result means a specific inherited mutation has been identified in one of your genes. This does not mean you already have cancer, nor does it guarantee that you will develop it. It indicates a higher-than-average risk, allowing you and your healthcare team to take proactive steps such as more frequent screening, lifestyle modifications, or considering preventative treatments depending on your circumstances.
Negative Result
A negative result means no harmful inherited mutations were found in the genes tested. This can be reassuring but does not eliminate overall cancer risk, as lifestyle, environment, or untested mutations may still influence outcomes. Standard screening may still be recommended based on age, sex, and medical history.
Variant of Uncertain Significance (VUS)
Sometimes a genetic change is detected whose impact on cancer risk is not yet fully understood, called a Variant of Uncertain Significance (VUS). It does not indicate increased risk, but current science cannot classify it as harmful or harmless. Over time, research may reclassify the variant, and patients will be updated accordingly.
Guided Interpretation and Support
At London Genetics, every result is explained in the context of your personal and family history. Whether positive, negative, or uncertain, you receive detailed guidance and support to help decide the most appropriate next steps for your health and peace of mind.
The Role of Genetic Counselling
Genetic counselling plays a crucial role in the process of Cancer Genetic Testing, helping patients understand the implications of their results for both themselves and their families. At London Genetics, our trained genetic counsellors provide expert guidance, ensuring that you are fully informed and supported every step of the way.
1. Understanding your results
After your test, the counsellor will explain what the findings mean in plain, accessible language. Whether your results are positive, negative, or a Variant of Uncertain Significance (VUS), the counsellor will clarify your risk level and outline potential next steps. This ensures that you leave the consultation with a clear understanding, not confusion or unnecessary worry.
2. Personal and family implications
Genetic changes can have consequences beyond the individual tested. A positive result may indicate that close family members could also be at higher risk. Genetic counselling helps families understand who may benefit from testing, how to communicate results sensitively, and what preventive measures might be appropriate.
3. Emotional support and decision-making
Receiving genetic test results can be overwhelming. Counsellors provide compassionate support, helping patients manage anxiety or uncertainty and make informed choices about screening, preventive measures, or lifestyle changes. This guidance ensures that decisions are tailored to your personal circumstances and values.
4. Long-term follow-up
Genetic counselling is not a one-time service. As new research emerges, or if circumstances change, counsellors may provide updated advice, helping you and your family navigate evolving information and opportunities for prevention.
By combining scientific expertise with personalised support, genetic counselling ensures that Cancer Genetic Testing translates into meaningful, actionable insights — empowering patients and their families to take control of their health with confidence.
Cancer Genetic Testing: Benefits and Limitations
Cancer Genetic Testing offers valuable insights into inherited cancer risk. At London Genetics, we provide a balanced view of its benefits and limitations to help individuals make informed health decisions.
Hover over each box for more detailed information!
Informed decision-making is key. By understanding both benefits and limitations, patients can approach Cancer Genetic Testing with realistic expectations, ensuring meaningful and actionable insights for themselves and their families.
The Role of Whole Genome Screening
Whole Genome Screening (WGS) represents an advanced approach in the field of Cancer Genetic Testing, allowing a thorough analysis of an individual’s entire genetic code. Unlike traditional tests that focus on specific genes associated with cancer, WGS examines all of a person’s DNA, providing a more comprehensive view of inherited risks.
1. Predictive insights for healthy individuals
One of the key advantages of WGS is its potential use in individuals who are currently healthy. By identifying genetic variations linked to higher cancer risk, this screening enables proactive decision-making. People can consider personalised monitoring, early interventions, or lifestyle changes that may reduce the likelihood of cancer developing.
2. Early detection and personalised prevention
By understanding genetic predispositions before symptoms arise, WGS can guide tailored prevention strategies. This may include more frequent or specialised screening for certain cancers, as well as personalised advice on diet, exercise, or medical interventions.
3. Implications for family members
Because inherited mutations can affect relatives, WGS results may also provide valuable insights for family members. Knowledge of potential risks allows relatives to seek testing and take preventative measures if necessary.
4. Limitations and considerations
While WGS offers unprecedented insight, it is important to note that not all detected genetic variations are fully understood. Some results may be of uncertain significance, and WGS does not eliminate the risk of cancer entirely. Ethical, emotional, and privacy considerations must also be taken into account before proceeding.
At London Genetics, WGS is offered alongside expert counselling to help patients interpret results and make informed choices. By integrating cutting-edge science with personalised guidance, whole genome screening represents a major step forward in proactive, preventive healthcare.
Why Choose London Genetics?
When it comes to Cancer Genetic Testing, choosing a provider with both expertise and a patient-centred approach is essential. London Genetics combines advanced technology with decades of clinical experience to ensure accurate, reliable, and personalised care.
1. Expertise of specialists
At the heart of London Genetics is a team of highly qualified professionals, including renowned specialists such as Dr. Ehsan Ghiyour Karimiani, who has extensive experience working within the NHS. Their deep understanding of hereditary cancers, combined with practical clinical experience, ensures that every test is interpreted accurately and responsibly.
2. Personalised care
Every patient receives individual attention. From the initial consultation to result interpretation and follow-up, London Genetics tailors guidance to your specific medical history, family background, and personal concerns.
3. Cutting-edge technology
London Genetics utilises the latest in genetic testing technology, including multi-gene panels and, where appropriate, whole genome screening. This allows for a thorough and precise assessment of inherited cancer risks.
4. Comprehensive support
Beyond the science, London Genetics places a strong emphasis on patient support. Genetic counselling is provided at every stage, ensuring that patients fully understand their results and the implications for themselves and their families.
5. Trusted and reputable service
With a track record of excellence and a commitment to ethical, patient-centred care, London Genetics has established itself as a leading provider of Cancer Genetic Testing in the UK. Choosing London Genetics means not only accessing cutting-edge testing, but also receiving expert guidance and compassionate support throughout your healthcare journey.
What You Can Expect
By the end of your Cancer Genetic Testing journey, you’ll have far more than a laboratory report — you’ll have genuine clarity about your own inherited cancer risk.
A clear understanding of your genetic risk — You’ll know exactly what your results mean, explained in plain, honest terms rather than complex scientific language.
A personalised prevention plan — Where relevant, you’ll receive clear recommendations on more frequent screening, lifestyle adjustments, or preventive options worth considering with your GP or specialist.
Answers for the wider family — Should a mutation be identified, you’ll have valuable information to share with relatives, helping them consider testing and take proactive steps of their own.
Confidence in your decisions — Whatever your results show, choices about screening, prevention, or family planning are made on solid, evidence-based ground, rather than uncertainty.
Reduced anxiety, more reassurance — Many patients find that even complex information feels far more manageable once it’s properly explained, replacing fear of the unknown with a genuine sense of control.
Ongoing support as new questions arise — Your relationship with your counsellor doesn’t end once your results are explained; further guidance remains available whenever you need it, including as research and understanding continue to evolve.
This is what makes Cancer Genetic Testing so valuable — not certainty about every outcome, but genuine clarity, confidence, and a clear path towards protecting your long-term health and that of your family.
Conclusion: Cancer Genetic Testing
Cancer Genetic Testing provides powerful insights into inherited cancer risks, but the true value depends on informed decision-making. Understanding your results, considering implications for both yourself and your family, and weighing benefits and limitations are essential to using this information effectively.
Personalised Guidance Matters
At London Genetics, we emphasise the importance of personalised guidance. Expert genetic counselling ensures that you fully understand your options and can make choices aligned with your health goals and personal circumstances.
Take the First Step with Confidence
If you are considering Cancer Genetic Testing, speak with the London Genetics team. Our specialists provide compassionate support and tailored advice, helping you navigate the process with clarity and confidence. Taking this first step empowers you with knowledge, reassurance, and the ability to pursue proactive, preventive healthcare.
Ready to take control of your health? Book your consultation with London Genetics today and discover how our expert genetic testing services can support your journey to personalised healthcare.
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Dr Ehsan Karimiani
In this section you can check frequently asked questions.
What is Cancer Genetic Testing?
Cancer Genetic Testing examines your DNA to identify inherited mutations that may increase your risk of developing certain cancers. It helps predict risk, guide personalised screening, and inform preventative strategies.
Who should consider genetic testing?
Testing is often recommended for individuals with a strong family history of cancer, a personal history of early-onset cancer, multiple types of cancer in one individual, or a known genetic mutation in the family. Your doctor or a genetic counsellor can help determine if testing is suitable for you.
How is the test performed?
The test usually involves a simple blood draw or a saliva sample. The sample is sent to a specialised laboratory, where your DNA is analysed for specific cancer-related gene mutations.
How long does it take to get results?
Results typically take several weeks, depending on the complexity of the analysis. Once ready, a genetic counsellor or specialist will review the findings with you.
Is Cancer Genetic Testing covered by health insurance?
Coverage depends on your private health insurance provider and policy. We’d recommend checking directly with your insurer before booking, and our team can provide documentation to support any claim.
What happens if my result comes back as a Variant of Uncertain Significance (VUS)?
A VUS means a genetic change has been detected, but its impact on cancer risk isn’t yet fully understood. Your counsellor will explain what this means in your specific context, and you’ll be updated if future research allows the variant to be reclassified.
Can other family members be tested if a mutation is found?
Yes, where relevant. If a mutation is identified, testing other family members can help clarify who else may be at higher risk, and your counsellor will guide you on the most sensible approach for your family.
Does a negative result mean I have no cancer risk at all?
No. A negative result means no harmful mutations were found in the genes tested, which can be genuinely reassuring, but it doesn’t eliminate overall cancer risk, as lifestyle, environment, or untested genes may still play a role.
Will I need to attend an appointment in person?
Both in-person and online consultations are available, with pre-test counselling and result interpretation often possible remotely. Sample collection, however, may require a brief in-person visit, depending on your circumstances.
